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If you’ve lived with allergies or asthma, you may have already been dealing with daily inhalers, allergy medications, and maybe even steroids. But when the symptoms keep coming back anyway, it can be exhausting and downright frustrating. Fortunately, there’s a new chapter in allergy and asthma care that’s giving people real hope: allergy biologics.
You can think of
biologics as high-tech problem solvers. Instead of just calming symptoms, they address the root cause of your inflammation, helping to prevent flare-ups before they start. Two of the most talked-about biologics options today are Xolair and Tezspire, as they’ve been life-changing for many who thought they were out of options.
At
Premier Allergy of Texas, we help you figure out which path fits your health story best. We’ll explain how each biologic works, answer your questions, and guide you toward a plan that helps you breathe easier and live better.
Let’s Find the Right Biologic for You
Simply put, biologics are lab-made antibodies designed to target very specific parts of your immune system. Rather than treating all your symptoms at once, this treatment goes straight to the source of the inflammation that’s causing your problems.
Here’s how they differ from traditional allergy or
asthma treatments:
Doctors often recommend
biologics for asthma when standard treatments like inhalers or antihistamines aren’t enough. At
Premier Allergy of Texas, we use advanced testing to guide you toward the biologic that best fits your needs.
Now that you know how biologics work, let’s talk about two of the most popular options: Xolair and Tezspire. Both are powerful tools in managing difficult-to-control asthma and allergies, but they work in slightly different ways and are approved for different conditions.
Understanding the difference between Xolair and
Tezspire can help you and your allergist decide which option may be the best fit for your needs.
| Feature | Xolair (omalizumab) | Tezspire (tezepelumab) |
|---|---|---|
| Mechanism of action | Xolair asthma treatment blocks IgE, the antibody that triggers allergic reactions and airway inflammation. | Tezspire blocks TSLP, an “alarm signal” that starts inflammation pathways in asthma. |
| Eligibility | Doctors often prescribe Xolair for allergic asthma with elevated IgE levels, confirmed by testing. | Doctors prescribe Tezspire for multiple asthma types, even when IgE or eosinophil levels are not high. |
| FDA-approved age groups | The FDA has approved Xolair for patients ages six and older for asthma, and for ages 12 and older for chronic hives. | The FDA has approved Tezspire for patients ages 12 and older with asthma. |
| Dosing and administration | A healthcare provider gives Xolair as an injection every two to four weeks in a clinic, with the dose based on weight and IgE levels. | A healthcare provider gives Tezspire as an injection once every 4 weeks. |
| Common side effects | Patients may experience injection site reactions, mild headaches, or fatigue. | Patients may experience injection site reactions, mild headaches, or fatigue. |
| Rare but serious side effects | In rare cases, patients may experience a severe allergic reaction (anaphylaxis). | In rare cases, patients may experience a severe allergic reaction (anaphylaxis). |
| Efficacy evidence | Clinical trials show that Xolair reduces flare-ups and improves quality of life for allergic asthma and chronic hives. | Clinical trials show that Tezspire asthma treatment reduces flare-ups and improves quality of life across multiple asthma types. |
Learning about the treatment process can help you feel prepared and confident before starting Xolair or Tezspire. Here’s an overview of what typically happens:
Your allergist will review your medical history, perform lung function tests, and order lab work to determine eligibility.
The first dose is often given in the clinic so your doctor can monitor you for any immediate reactions. At this time, your provider will explain how Xolair works for allergies, focusing on its ability to block IgE antibodies that cause allergic reactions and airway inflammation.
You will have regular check-ins to monitor symptoms, side effects, and progress. Xolair is typically administered every two to four weeks, while Tezspire is given once a month. During these visits, your doctor will also discuss how Tezspire works to block the inflammatory signals that contribute to asthma symptoms.
Your doctor may recommend continuing, switching, or stopping treatment based on how you respond over the first few months.
Once you’ve thought through your options, the next step is finding the right partner to guide you through the process.
If you’re still wondering which is better, Xolair or Tezspire, our allergists can help you. This is one of the most common questions we hear, and the answer depends on your unique symptoms, medical history, and test results.
Here’s how we help you make the most informed choice:
We take the time to understand your symptoms, triggers, and test results. This helps us determine the right biologic treatment fit for you.
We regularly check in, track your improvements, and make adjustments to ensure your treatment plan stays on track and delivers the best results.
We help you navigate insurance approvals and connect you with resources to make your medication accessible and affordable.
Choosing a biologic treatment doesn’t have to be stressful. With our expertise, guidance, and compassionate care, you can focus on what matters most—feeling better and living life to the fullest.
Xolair and Tezspire both offer powerful relief for allergy and asthma sufferers, but their differences matter when it comes to finding the best fit for you. For many patients, especially those who haven’t found relief with standard medications, biologics for severe asthma and allergy can be a game changer.
The right choice depends on your symptoms, health history, and long-term goals. That’s why having a knowledgeable, compassionate care team by your side makes all the difference.
Our allergy experts at
Premier Allergy of Texas take the time to understand your needs and walk you through your options, step by step. If you’re ready to explore whether Xolair, Tezspire, or another approach is right for you, schedule a consultation with our team today. We’ll help you breathe easier — and live better — with confidence.
Say Goodbye to Allergy Flare-Ups
Yes, it’s possible to switch, but doing so requires careful medical supervision. Your allergist will assess your treatment response, side effects, and lab results before making a transition plan. Sometimes, a short break between treatments is needed to avoid overlapping effects.
It varies from person to person. Some patients report improvement in as little as a few weeks, while for others it may take three to six months. Consistent follow-ups help track your progress and adjust your plan if needed.
At first, yes. Most patients continue their existing asthma or allergy meds until their biologic shows full benefits. Over time, your doctor may reduce your other medications if your symptoms improve.
Absolutely. While Xolair and Tezspire target inflammation directly, strategies such as avoiding triggers, staying active, managing stress, and getting quality sleep can also boost your overall results.
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